Micro-Computed Tomography Analysis of Subchondral Bone Regeneration Using Osteochondral Scaffolds in an Ovine Condyle Model

Osteochondral scaffold technology has emerged as a promising therapy for repairing osteochondral defects. Recent research suggests that seeding scaffolds with bone marrow concentrate (BMC) may enhance tissue regeneration. To examine this hypothesis, study examined subchondral regeneration in and without BMC. Ovine stifle condyle models were used the vivo study. Two systems (8 mm diameter 10 thick) BMC implanted into femoral condyle, tissues retrieved after six months. The condyles (with in) using micro-computed tomography scans (micro-CT), micro-CT data further analysed by ImageJ respect to trabecular thickness, volume total ratio (BV/TV) ratio, degree of anisotropy bone. Statistical analysis compared between groups sub-set regions. These results mostly insignificant (p < 0.05), exception when comparing composition region. Additional trends observed. suggest addition did not significantly affect defects However, provides which guide development future treatments.